Caryophyllene is unique among terpenes as it can interact with cannabinoid receptors in the body

https://loop.frontiersin.org/people/2700538/overview

Caryophyllene is unique among terpenes as it can interact with cannabinoid receptors in the body. With a spicy, peppery scent, it may help alleviate pain and inflammation while offering potential therapeutic benefits for anxiety and depression