Botox in the DAO muscles can soften a perpetually sad look by reducing downward pull on the mouth corners over time.

https://www.tumblr.com/stealthilyshiftingspire/801397355572314112/botox-mechanism-made-simple-blocking-signals-for

Botox in the DAO muscles can soften a perpetually sad look by reducing downward pull on the mouth corners over time.